{"id":12966,"date":"2025-11-05T12:25:00","date_gmt":"2025-11-05T09:25:00","guid":{"rendered":"https:\/\/otexe.com\/?p=12966"},"modified":"2025-11-05T22:57:08","modified_gmt":"2025-11-05T19:57:08","slug":"malocclusion-as-a-factor-of-systemic-inflammation","status":"publish","type":"post","link":"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/","title":{"rendered":"Malocclusion as a factor of systemic inflammation"},"content":{"rendered":"<h2>Malocclusion and systemic consequences: a brief summary of the evidence<\/h2>\n<p>Malocclusion, or misaligned bite, is a widespread oral health issue associated with a range of diseases and conditions that can affect a patient&#8217;s overall health and quality of life. The presented evidence highlights the link between oral disorders associated with malocclusion and systemic diseases; this requires dentists to be attentive to potential systemic consequences during examination and treatment planning. <\/p>\n<h2>Key factors<\/h2>\n<ul>\n<li>Oral bacteria have been detected in Alzheimer&#8217;s disease foci and atherosclerotic plaques, indicating the potential translocation of pathogens from the oral cavity into the systemic circulation and tissues.<\/li>\n<li>Periodontal disease has been consistently documented as a risk factor for cardiovascular pathology, stroke, and impaired glycemic control in patients with diabetes.<\/li>\n<li>Evidence has accumulated suggesting that the systemic dissemination of oral bacteria and their products (e.g., LPS) can initiate or sustain chronic systemic inflammation, contributing to polyetiological diseases.<\/li>\n<\/ul>\n<h2>Implications for dental practice<\/h2>\n<h3>Clinical significance and screening<\/h3>\n<p>For the clinician\u2014dentist, it is important to consider that the signs and symptoms of malocclusion often coexist with periodontal disorders, impaired hygiene, and increased colonization by pathogens. <strong>During history taking and examination, occlusal disorders, periodontal indices (PD, CAL, BOP), plaque index, and caries status should be documented.<\/strong><\/p>\n<h3>Pathogenetic mechanisms &#8211; a brief explanation<\/h3>\n<p>The mechanisms linking oral infection to systemic conditions include the mobilization of bacteria and bacterial components into the bloodstream during periodontitis, the activation of a systemic inflammatory response (elevated CRP, cytokines), and local effects on the vascular wall at sites of atherosclerotic lesions. These processes are complex and multifactorial. <\/p>\n<h3>Management recommendations and interdisciplinary collaboration<\/h3>\n<ul>\n<li>Include assessment of periodontal status and systemic disease risks in the overall dental examination plan.<\/li>\n<li>\u041f\u0440\u0438 \u043d\u0430\u043b\u0438\u0447\u0438\u0438 \u0432\u044b\u0440\u0430\u0436\u0435\u043d\u043d\u043e\u0433\u043e \u043f\u0430\u0440\u043e\u0434\u043e\u043d\u0442\u0438\u0442\u0430 \u0438 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432 \u0440\u0438\u0441\u043a\u0430 (\u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e\u2011\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u0434\u0438\u0430\u0431\u0435\u0442, \u043d\u0435\u0439\u0440\u043e\u0434\u0435\u0433\u0435\u043d\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u044b\u0435 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f) \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043e\u0432\u044b\u0432\u0430\u0442\u044c \u043a\u043e\u043e\u0440\u0434\u0438\u043d\u0430\u0446\u0438\u044e \u0441 \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u043e\u043c, \u043a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u043e\u043c, \u044d\u043d\u0434\u043e\u043a\u0440\u0438\u043d\u043e\u043b\u043e\u0433\u043e\u043c \u0438\u043b\u0438 \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u043e\u043c \u0434\u043b\u044f \u0441\u043e\u0432\u043c\u0435\u0441\u0442\u043d\u043e\u0433\u043e \u0443\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u0438\u044f \u0440\u0438\u0441\u043a\u0430\u043c\u0438.<\/li>\n<li>Implement active periodontal therapy (SRP techniques, inflammation control, hygiene motivation), occlusal correction, and, if necessary, orthodontic\/prosthetic treatment to restore functional homeostasis, which may reduce the inflammatory burden.<\/li>\n<li>Assess and optimize associated risk factors: tobacco use, glycemic control, dyslipidemia, etc.<\/li>\n<\/ul>\n<h2>Practical tips for dentists<\/h2>\n<h3>Prevention and monitoring<\/h3>\n<p>Regular monitoring of periodontal parameters, educating patients on effective hygiene techniques, and planning early orthodontic or prosthetic correction for functional disorders can help reduce chronic inflammation in the oral cavity.<\/p>\n<h3>Documentation and patient awareness<\/h3>\n<p>Document the connection between identified oral issues and potential systemic risks, discuss with the patient the need for interdisciplinary follow-up and medical consultations in the presence of risk factors.<\/p>\n<h2>Expert commentary<\/h2>\n<p>Although associations between oral infections and systemic diseases are well-documented, causal relationships remain a subject of research. From a practical standpoint, clinicians should rely on evidence-based practices for screening and treating periodontal and occlusal disorders, consider oral treatment as part of comprehensive patient management, and establish communication with general practitioners and relevant specialists.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Malocclusion and systemic consequences: a brief summary of the evidence Malocclusion, or misaligned bite, is a widespread oral health issue associated with a range of diseases and conditions that can affect a patient&#8217;s overall health and quality of life. The presented evidence highlights the link between oral disorders associated with malocclusion and systemic diseases; this [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":4862,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"quote","meta":{"pmpro_default_level":"","footnotes":""},"categories":[240],"tags":[],"class_list":["post-12966","post","type-post","status-publish","format-quote","has-post-thumbnail","hentry","category-scientific-articles","post_format-post-format-quote","pmpro-has-access"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Malocclusion as a factor of systemic inflammation - OTEXE<\/title>\n<meta name=\"description\" content=\"Malocclusion, or misaligned bite, is a widespread oral health issue associated with a range of diseases and conditions that can affect a patient&#039;s overall health and quality of life. The presented evidence highlights the link between oral disorders associated with malocclusion and systemic diseases; this requires dentists to be attentive to potential systemic consequences during examination and treatment planning.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Malocclusion as a factor of systemic inflammation - OTEXE\" \/>\n<meta property=\"og:description\" content=\"Malocclusion, or misaligned bite, is a widespread oral health issue associated with a range of diseases and conditions that can affect a patient&#039;s overall health and quality of life. The presented evidence highlights the link between oral disorders associated with malocclusion and systemic diseases; this requires dentists to be attentive to potential systemic consequences during examination and treatment planning.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/\" \/>\n<meta property=\"og:site_name\" content=\"OTEXE\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/otexeworld\/reviews\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-05T09:25:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-05T19:57:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/otexe.com\/wp-content\/uploads\/2025\/08\/quang-tri-nguyen-vckdjzo7ig0-unsplash.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"news bot\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@otexeworld\" \/>\n<meta name=\"twitter:site\" content=\"@otexeworld\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"news bot\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/\"},\"author\":{\"name\":\"news bot\",\"@id\":\"https:\/\/otexe.com\/en\/#\/schema\/person\/9140d95fa9a582da764836aeeea66419\"},\"headline\":\"Malocclusion as a factor of systemic inflammation\",\"datePublished\":\"2025-11-05T09:25:00+00:00\",\"dateModified\":\"2025-11-05T19:57:08+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/\"},\"wordCount\":477,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/otexe.com\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/otexe.com\/wp-content\/uploads\/2025\/08\/quang-tri-nguyen-vckdjzo7ig0-unsplash.jpg\",\"articleSection\":[\"Scientific articles\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/\",\"url\":\"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/\",\"name\":\"Malocclusion as a factor of systemic inflammation - OTEXE\",\"isPartOf\":{\"@id\":\"https:\/\/otexe.com\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/otexe.com\/en\/malocclusion-as-a-factor-of-systemic-inflammation\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/otexe.com\/wp-content\/uploads\/2025\/08\/quang-tri-nguyen-vckdjzo7ig0-unsplash.jpg\",\"datePublished\":\"2025-11-05T09:25:00+00:00\",\"dateModified\":\"2025-11-05T19:57:08+00:00\",\"description\":\"Malocclusion, or misaligned bite, is a widespread oral health issue associated with a range of diseases and conditions that can affect a patient's overall health and quality of life. 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